-, Hochhaus A., Larson R.A., Guilhot F., Radich J.P., Branford S., Hughes T.P., Baccarani M., Deininger M.W., Cervantes F., Fujihara S., et al. A study known as IPASS illustrates how treatment response can vary by EGFR mutation status. Presented at: ASCO Annual Meeting; May 31-June 4, 2019; Chicago. Patients ultimately develop disease progression, often driven by acquisition of a second T790M EGFR TKI resistance mutation. The overall response to treatment was 80% with Tagrisso compared to 75% with standard of care treatment. The combination of EGFR TKI and FGFR1 or MEK inhibitors may offer an attractive therapeutic strategy for NSCLC. This progress is critical because, in non-small cell lung cancer patients with ALK alterations, disease progression tends to occur in the brain. Tagrisso provided a significant progression-free survival benefit in Asian patients with EGFR-mutated NSCLC. The study, conducted in East Asia, enrolled patients with advanced adenocarcinoma of the lung. Resistance to Tagrisso will ultimately develop in nearly all patients, and subsequent treatment options to overcome this resistance are needed. They work by inhibiting growth factor activity and controlling cell division. Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial. Osimertinib or platinum–pemetrexed in EGFR T790M–positive lung cancer. Pictured above is the sequencing strategy in which an earlier-generation EGFR TKI, erlotinib, is used in the first line, followed by the later-generation EGFR TKI osimertinib after progression in the setting of acquired T790M mutation. The most common side effects among patients treated with Tarceva were rash (49%) and diarrhea (20%). Guidelines from the International Association for the Study of Lung Cancer (IASLC) have been developed and they recommend EGFR mutation testing at initial diagnosis of all lung cancer patients. Presented at the 2012 annual meeting of the American Society of Clinical Oncology, June 1-5, 2012, Chicago, IL. N Engl J Med. Gmeiner WH, Miller LD, Chou JW, Dominijanni A, Mutkus L, Marini F, Ruiz J, Dotson T, Thomas KW, Parks G, Bellinger CR. Please enable it to take advantage of the complete set of features! Eaby B, Culkin A, Lacouture ME. Drugs called EGFR inhibitors can block the signal from EGFR that tells the cells to grow. Compared with traditional platinum-based combination chemotherapy, EGFR TKI monotherapy has become the recommended treatment strategy and the cornerstone of combined therapy for NSCLC patients with an EGFR mutation*. Despite this impressive effect, the optimal sequencing of osimertinib, whether in the first line or as subsequent therapy after the failure of earlier-generation EGFR TKIs, is not clear. An interdisciplinary consensus on managing skin reactions associated with human epidermal growth factor receptor inhibitors. First-generation EGFR tyrosine kinase inhibitors (EGFR TKI) provide significant clinical benefit in patients with advanced EGFR -mutant (EGFRm+) non–small cell lung cancer (NSCLC). Curr Opin Oncol. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. See this image and copyright information in PMC. eCollection 2020. Serious side effects were also less common in the Tarceva group. Keep up with the growing number of precision medicines targeting specific mutations in lung cancer. Those receiving the Tarceva - Cyramza combination survived on average 19.4 months compared to 12.4 months for those treated with Tarceva alone. Fukuoka M, Wu Y-L, Thongprasert S et al. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are being increasingly used to treat lung cancer… The researchers concluded that Gilotrif appears to be an effective treatment option for patients with advanced squamous cell lung cancer. 2007;25:4743–50. doi: 10.1056/NEJMoa1609324. N Engl J Med.  |  For example Avastin combined with Tarceva improved progression free survival by 9-10 months when used as first or second line treatment for advanced EGFR + NSCLC. Purpose: Given the unprecedented efficacy of EGFR tyrosine kinase inhibitors (TKI) in advanced EGFR-mutant lung cancer, adjuvant TKI therapy is an appealing strategy.However, there are conflicting findings regarding the potential benefit of adjuvant EGFR-TKI in patients with lung cancer harboring EGFR mutations. This leads to the uncontrolled and excessive growth of the cancer cell. , Cobo M, Wu Y-L, Chen G et al Apr 16 ; (! 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